Global Summit on Mechanobiology and Mechanomedicine on March 6-7, 2025, ISEC building at Northeastern University on 805 Columbus Ave, Boston, MA, USA
Wednesday March 5
Arriving in Boston, MA, USA and check into Sheraton Boston Hotel (39 Dalton St, Boston, MA; Phone:(617) 236-2000), or The Verb Hotel, 1271 Boylston St, Boston, MA; Phone: (617) 566-4500 or The Inn at Longwood,342 Longwood Ave., Boston, MA; Phone: (617) 731-4700.
Free on your own schedule
Thursday March 6
| Time EST | Agenda Item | Speaker(s) | Location |
| 08-08:40 | Registration and Continental Breakfast | Atrium of ISEC | |
| 08:40-09:00 | Opening Welcome Remarks | Ning Wang, Director of Institute for Mechanobiology, and University leadership | 102 ISEC Auditorium |
| 09-09:30 | Keynote lecture (virtual), “Mechanotransduction in Health and Disease”, Shu Chien of UCSD | Introduction by Arthur Coury, University Distinguished Professor, Northeastern University | 102 ISEC Auditorium |
| 09:30-10:40 | Session I Cardiovascular Mechanohomeostasis | Moderators: Eno Ebong, Guohao Dai | 102 ISEC Auditorium |
| 09:30-10:00 | Plenary Lecture, “Vascular endothelial fluid shear stress mechanotransduction in development and disease” | Martin Schwartz of Yale | 102 ISEC Auditorium |
| 10:00-10:15 | Invited Talk, “Mechanoregulatory mechanisms: Diversity and redundancy in an unpredictable world” | Christopher Chen of Boston University | 102 ISEC Auditorium |
| 10:15-10:20 | Invited Short Talk, “Engineering Human Ventricular Chambers with Pumping Function to Study Hypertension” | Hyeonyu Kim of Northeastern University | 102 ISEC Auditorium |
| 10:20-10:40 | Panel Discussion | Panel Chair: Jay Humphrey of Yale; Panelists: Kevin Chalut, Mian Long, Jessica Oakes | 102 ISEC Auditorium |
| 10:40:10:45 | Group Photo | Atrium of ISEC | |
| 10:45-11:00 | Coffee Break | Atrium of ISEC | |
| 11:00-12:20 | Session II Immunomechano-oncology. | Moderators: Herbert Levine, Pere Roca-Cusachs Soulere | 102 ISEC Auditorium |
| 11:00-11:30 | Plenary Lecture, “Tissue rigidity spurs mutations & goads tumoricidal macrophages” | Dennis Discher of UPENN | 102 ISEC Auditorium |
| 11:30-11:45 | Invited Talk, “The power of softness in mechano-onco-immunology” | Bo Huang of Chinese Academy of Medical Sciences | 102 ISEC Auditorium |
| 11:45-12:00 | Invited Talk, “Mechanotransduction through delta glutamate receptor 1” | Cheng Zhu of Georgia Institute of Technology | 102 ISEC Auditorium |
| 12:00-12:20 | Panel Discussion | Panel Chair: Herbert Levine; Panelists: Pere Roca-Cusachs Soulere, Song Li, Ning Wang | 102 ISEC Auditorium |
| 12:20-1:00 | Box Lunch Break and Poster session | Atrium of ISEC | |
| 1:00-2:20pm | Session III Tumor Microenvironment Mechanobiology | Moderators: Guy Genin, Peter Yingxiao Wang | 102 ISEC Auditorium |
| 1:00-1:30pm | Plenary Lecture, “Infiltration of T-cells into Tumors: Possible Roles of the ECM” | Herbert Levine of Northeastern Univ | 102 ISEC Auditorium |
| 1:30-1:45pm | Invited Talk, “ECM mechanics regulates the switch between fibrosis and regeneration” | Kevin Chalut of University of Cambridge | 102 ISEC Auditorium |
| 1:45-2:00pm | “Combined map of cell mechanics and transcriptome in preimplantation mouse embryos” | Ming Guo of MIT | 102 ISEC Auditorium |
| 2:00-2:20pm | Panel Discussion | Panel Chair: Guy Genin; Panelists: Bo Huang, Cheng Zhu, Peter Yingxiao Wang | 102 ISEC Auditorium |
| 2:20-2:35pm | Coffee Break | Atrium of ISEC | |
| 2:35-3:55pm | Session IV Tissue & Matrix Mechanobiology | Moderators: Sandra Shefelbine, Erin Cram | 102 ISEC Auditorium |
| 2:35-3:05pm | Plenary Lecture, “The Effects of Spaceflight on the Skeletal System” | Mary Bouxsein of HMS/BIDMS | 102 ISEC Auditorium |
| 3:05-3:20pm Invited Talk | Invited Talk, “Mechanochemistry of Collagen: The Potential for Direct Molecular Mechanotherapeutics in the Matrix” | Jeffrey Ruberti of Northeastern Univ | 102 ISEC Auditorium |
| 3:20 -3:35pm | “TRPV4-Mediated Mechanosensation in Schlemm’s Canal Cells: Role in Glaucoma” | Ross Ethier of Georgia Tech | 102 ISEC Auditorium |
| 3:35 -3:55pm | Panel Discussion | Chair, Jeffrey Ruberti; Panelists, Sandra Shefelbine, Erin Cram, Rouzbeh Amini | 102 ISEC Auditorium |
| 4:00 -6:00pm | Poster Session, Reception | 140 & 142 ISEC, ISEC Atrium | |
| 6-8:00pm | Dinner on your own; External Advisory Board (EAB) Meeting/Dinner (EAB members and university leadership only) |
Friday March 7
| Time EST | Agenda Item | Speaker(s) | Location |
| 8-8:50 | Continental Breakfast | Atrium of ISEC | |
| 8:50-10:40 | Session V Mechanics and Mechanotransduction of Cells | Moderators: Dennis Discher, Guy Genin | 102 ISEC Auditorium |
| 8:50-9:20 | Plenary Lecture, “Cell mechanics, revisited” | David Weitz of Harvard | 102 ISEC Auditorium |
| 9:20-9:35 | Invited Talk, “Understanding and engineering ECM-nucleus force transmission and mechanotransduction” | Pere Roca-Cusachs Soulere of University of Barcelona | 102 ISEC Auditorium |
| 9:35-10:05 | Plenary Lecture (virtual), “Biomechanical Analysis of the Transformation of Fibroblasts to Myofibroblasts” | Elliot Elson of WashU | 102 ISEC Auditorium |
| 10:05-10:20 | Invited Talk, “What are the biological principles of living cells“ | Ning Wang of Northeastern University | 102 ISEC Auditorium |
| 10:20-10:40 | Panel Discussion | Chair, Dennis Discher; Panelists, Martin Schwartz, Chris Chen, Kevin Chalut | 102 ISEC Auditorium |
| 10:45-11:00 | Coffee Break | Atrium of ISEC | |
| 11:00-12:20 | Session VI Mechanodiagnostics and Mechanotherapeutics | Moderators: Martin Schwartz, Song Li | 102 ISEC Auditorium |
| 11:00 -11:30 | Plenary Lecture, “From Mechanobiology to Mechanophysiology to Mechanotherapeutics” | Donald Ingber of Harvard | 102 ISEC Auditorium |
| 11:30-11:45 | Invited Talk, “Merging Humans and Machines by Harnessing Mechanics” | Xuanhe Zhao of MIT | 102 ISEC Auditorium |
| 11:45-12:00 | “Ultrasound Mechanogenetics for Cell-based ImmunoTherapy” | Peter Yingxiao Wang of USC | 102 ISEC Auditorium |
| 12:00-12:20pm | Panel Discussion | Chair, Martin Schwartz; Panelists, Abraham Joy, Emily Zimmerman, Amir Vahabikashi | 102 ISEC Auditorium |
| 12:20-1:00pm | Box Lunch Break | Atrium of ISEC | |
| 1-2:45pm | Session VII Emerging Technologies for Mechanobiology and Mechanomedicine | Moderators: Sara Hashmi, Maijia Liao | 102 ISEC Auditorium |
| 1:00-1:30pm | Plenary Lecture, “Mechanomedicine: From Diagnosis to Therapeutics” | Song Li of UCLA | 102 ISEC Auditorium |
| 1:30-1:45pm | Invited Talk, “Mechanobiology of Liver Injury and Regeneration” | Mian Long, Chinese Academy of Sciences | 102 ISEC Auditorium |
| 1:45-2:00pm | Invited Talk, “Mechanobiology through the lens of proteomics” | Nikolai Slavov of Northeastern University | 102 ISEC Auditorium |
| 2:00-2:15pm | Invited Talk, “Accelerating drug discovery with geometric and generative AI” | Wengong Jin of Northeastern University | 102 ISEC Auditorium |
| 2:15-2:20pm | Invited Short Talk, “Flexible 3D Bioelectronic Interfaces for Investigating the Mechanobiology of Neuromuscular Systems” | Amir Vahabikashi of Northeastern University | 102 ISEC Auditorium |
| 2:20-2:25pm | Invited Short Talk“Harnessing Synthetic Biology for Targeted Cell Engineering” | Lei Wang of Northeastern University | 102 ISEC Auditorium |
| 2:25-2:45pm | Panel Discussion | Chair, Becky Willits; Panelists, Guohao Dai, Frank Loth, Ming Guo | 102 ISEC Auditorium |
| 2:45-3:00pm | Best Poster Awards; Final Thoughts and Concluding Remarks | 102 ISEC Auditorium | |
| 3:00pm | Departing |
We would like to extend our sincerest gratitude and appreciation to our bronze sponsors.
